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Interaction terms between Ang-II stimulating AHMs with follow-up duration, mean SBP, and mean DBP were modelled

Improvement in symptoms can be seen within days to weeks of starting B12 supplementation

It increases VEGF receptor activity to promote new blood vessel formation, enhances collagen synthesis and organization, activates the ERK1/2 signaling pathway for cell proliferation and migration, and modulates inflammatory responses to optimize healing conditions

Meanwhile, NNMTi preserves lean body mass: it reduces fat accumulation without causing muscle loss, which is crucial for maintaining basal metabolism and preventing weight regain after dieting.These in vivo findings fully validate the efficacy and safety of NNMTi in obesity intervention, laying a solid foundation for its subsequent clinical research and drug development